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Here's what we have been up to!

New Paper on energy dissipation in LVAD flows is now out!

6/22/2023

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We at FLOWLab are super excited to share the publication of our latest manuscript titled "The relation between viscous energy dissipation and pulsation for aortic hemodynamics driven by a left ventricular assist device" is now published and available at the BMES journal Cardiovascular Engineering and Technology at the following link: ​https://link.springer.com/article/10.1007/s13239-023-00670-6. 

This work involved contribution from FLOWLab members Akshita Sahni and Kelly Cao and collaborator Jay D. Pal from University of Washington, Seattle. We discuss the specific aspects of viscous energy transport and dissipation due to the altered state of hemodynamics driven by LVAD outflow jet impingement on the aorta wall. This work was funded by the University of Colorado Anschutz Boulder (AB) Nexus research collaboration grant. Check out our paper (you can download an accessible author pre-print from our Publications page). Congratulations Team!
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New Pre-print on biorxiv!

6/12/2023

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We are excited to announce FLOWLab's latest preprint available on bioRxiv (link here) on studying clot flow interactions in vivo by integrating intravital imaging with in silico modeling. This work is led by FLOWLab PhD student Chayu Teeraratkul in collaboration with Maurizio Tomaiuolo and Timothy Stalker.

Intravital imaging of mouse laser injury model can provide high resolution information on hemostatic processes in vivo. However, quantifying the local flow environment and flow-clot interactions require additional work. Here, we use custom numerical methods to fill in hemodynamic and clot-flow interaction information based on experimental data from mouse laser injury models. We can obtain not only the flow patterns, but also flow-induced loading on the clot, and flow-mediated chemical transport in the clot environment, all while accounting for dynamic deformation behavior of the clot itself. The methodology and model predictions are validated against direct experimental observations on caged fluorescent albumin transport dynamics in the mouse injury model. Feel free to check out the preprint, and reach out to us with any questions/comments.
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FLOWLab Presentations at the sb3c 2023 meeting

6/3/2023

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FLOWLab members are presenting 3 podium talks at the 2023 Summer Biomechanics, Bioengineering, and Biotransport Conference hosted at Vail, Colorado. Doctoral students Chayut Teeraratkul and Ricardo Roopnarinesingh, and post-doctoral scholar Sreeparna Majee, are presenting their research - showcasing the spectrum of stroke and thrombosis research in our group. Details attached in the image alongside. Congratulations Chayut, Ricardo, and Sreeparna!
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Advertising our new pre-print on embolic stroke

6/1/2023

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We at FLOWLab are happy to share the latest preprint from our group on MedRxiv on evidence and mechanisms for embolic stroke in contralateral hemispheres from carotid artery disease, available at:
https://www.medrxiv.org/content/10.1101/2023.04.20.23288892v1
This work is authored by FLOWLab member Ricardo Roopnarinesingh and collaborator Michelle Leppert, and is part of our NIH funded study on embolic stroke mechanics. We thank NIH for the funding support, and Dr. Leppert for the wonderful collaboration. Please check out the pre-print, and reach out to us if you have any questions!
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FLOWLAB Undergraduate Exchange student experience

6/1/2023

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Over Fall 2022 and Spring 2023, FLOWLab hosted Guillermo Munoz Ovejero and Alvaro Carpio Chicote as international undergraduate research exchange students. This summer, Guillermo and Alvaro completed their stint with FLOWLab. During this time, they worked on a tilt control mechanism for studying vascular flows. Pictured here is their exit presentation with the entire FLOWLab team. We congratulate Guillermo and Alvaro on their wonderful work, and thank them for spending research time with us. A special word of thanks to FLOWLab members Thomas Puhr and Tandralee Chetia, who served as mentors for Guillermo and Alvaro throughout their program. 
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FLOWLAb Research presented at AHA stroke conference!

2/9/2023

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FLOWLab was excited to share some of the ongoing research on stroke, thrombosis, and hemostasis in the lab with investigators and industry partners at the American Heart Association International Stroke Conference on February 8-10 at Dallas, TX. We shared some of our preliminary results on quantification of stroke risks in heart failure patients on Left Ventricular Assist Devices support, which was conducted by FLOWLab alumnus Akshita Sahni, and in collaboration with Dr. Jay D. Pal from University of Washington Seattle. We thank the National Institutes of Health and the University of Colorado Anschutz Boulder (AB) Nexus research collaboration program for funding our efforts in these directions. Please check out the abstract indexed in Stroke journal at the following link: Abstract Here. Thank you American Heart Association for such a wonderful platform for us to share our work!
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Congrats to two Freshly Minted FLOWLab Graduates!

12/15/2022

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Huge congratulations to Tom Puhr and Summer Andrews - FLOWLab's latest MS Thesis graduates!! This winter they got the chance to walk in their regalia in celebration of completing their MS degree. Both Tom and Summer completed amazing thesis research, paving the way for new research directions in the group! FLOWLab is ever so fortunate to have worked with you, will always be proud as well as supportive of all your future accomplishments, and wishes you all the very best of successes and prosperity ahead! Congratulations Tom and Summer!
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FLowlab's first undergraduate exchange students

12/15/2022

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This year FLOWLab hosted its very first set of undergraduate exchange students - Guillermo Munoz Ovejero and Alvaro Carpio Chicote - who visited us from Madrid, Spain. They are working as undergraduate researchers on a design project to create a tilt control system to study the impact of gravity on blood flow and embolisms. This work was supervised by FLOWLab MS Thesis student Tom Puhr, will continue under the supervision of MS Thesis student Tandralee Chetia. As the Fall semester ended, Guillermo and Alvaro presented status update on their research project. And boy are we excited to see what they continue to do as they rejoin us in the Spring to complete their exchange program! 
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FLOWLab presentations at APS-DFD 2022 in Indianapolis!

11/18/2022

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 FLOWLab members will be presenting a cross-section of some of our ongoing research efforts at the 75th Annual Technical Meeting of the American Physical Society Division of Fluid Dynamics. The complete list of presentations are provided in the photograph alongside. If you are attending APS-DFD as well, and/or are interested in any of these areas - please connect with us, and we would be happy to chat!

Looking forward to engaging with fellow fluid mechanicians at the APS DFD meeting. 

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Summer andrews successfully defends her ms thesis!

11/17/2022

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FLOWLab member and MS Thesis student Summer Andrews successfully defended her MS Thesis based on some awesome in silico modeling research on Trans-arterial Radioembolization in Hepato-cellular Carcinoma (liver cancers). Summer's research was born out of an inter-disciplinary collaboration with Dr. Premal Trivedi at the University of Colorado Anschutz Medical Campus. In addition to her research, Summer also served as a mentor for FLOWLab's virtual summer research internship program, and contributed to spearheading several FLOWLab socials. Congratulations Summer!
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Thomas Puhr Successfully Defends his MS Thesis!

11/15/2022

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FLOWLab member and MS Thesis student Thomas Puhr successfully defended his MS Thesis based on his amazing research on design and testing of an n vitro benchtop flow loop for investigation of embolic particle transport and distribution. This work was supported in its very early stages by the Oak Ridge Associated Universities (ORAU) through a Ralph Powe Junior Faculty Enhancement Award (awarded to FLOWLab PI Prof. Mukherjee). In addition to his research, Tom also served as mentor for the CU Science Discovery Program mentoring high school students, and served actively to advance FLOWLab's DEI initiatives. Congratulations Tom!
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FLOWLab participates in 2022 CU Science Discovery Program!

7/20/2022

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FLOWLab is delighted to serve as hosts for four amazing and talented young scientists through the Summer 2022 CU Science Discovery Program. Participants Jai Maurya, Connor Edelheit, Lily Brustkern, and Reid Sprague were part of the 2022 Boulder STEM Experience program. They were mentored and led by FLOWLab PhD Student Lindsey Nast, and MS Thesis student Thomas Puhr. The participants worked on different biofluids research projects pertaining to experimental flow visualization and embolus transport, as well as blood flow in retinal arteries in the eye. FLOWLab thanks the CU ScienceDiscovery Program team, and in particular Kathryn Penzkover, for their support and assistance with initiatives like these!
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New preprint on energy dissipation in lvad flows now out!

7/18/2022

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FLOWLab is pleased to announce the release of a new preprint titled "The Relation Between Viscous Energy Dissipation And Pulsation For Aortic Hemodynamics Driven By A Left Ventricular Assist Device". This is the second manuscript in a series of manuscripts originating from a study on stroke risk assessment in heart failure patients on an LVAD support in collaboration with Dr. Jay Pal from University of Washington Seattle. The research was led by FLOWLab MS student Akshita Sahni, and ably supported by talented undergraduate student Kelly Cao. We are grateful for generous funding from the University of Colorado Anschutz-Boulder Nexus Research Collaboration Grant. The preprint can be accessed on medRxiv at this link. We look forward to comments, questions, and feedback from the broader scientific community. 
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New Preprint on Hemodynamic Analysis for heart failure patients on LVAD!

7/4/2022

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FLOWLab is excited to announce that we have released a new preprint reporting a quantitative hemodynamic analysis for flow in the aorta of heart failure patients on mechanical circulatory support. This preprint is titled "Quantitative Assessment of Aortic Hemodynamics for Varying Left Ventricular Assist Device Outflow Graft Angles and Flow Pulsation" and is available on medRxiv at the following link: https://doi.org/10.1101/2022.06.17.22276555. This is the first in a series of forthcoming studies we have recently completed on hemodynamics in patients on LVAD support, and their interrelationship with stroke and cerebrovascular accident risks. The series of studies was led by Akshita Sahni, in collaboration with Dr. Jay D. Pal and Dr. Erin E. McIntyre. The study was supported by a University of Colorado Anschutz-Boulder Nexus Research Collaboration Grant. We look forward to comments, questions, and feedback from the broader scientific community. 

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NEW preprint on infection transmission now out on medrxiv!

5/26/2022

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We are excited to announce that we have a.new preprint on flow-mediated infection transmission for airborne infections, which combines social interaction dynamics models with fluid mechanics. Titled "A Mesoscale Agent Based Modeling Framework For Flow-mediated Infection Transmission In Indoor Occupied Spaces", this preprint can be accessed on medRxiv at this link. This is particularly exciting for us as this work was driven by our first remote visiting intern Gauri Wadhwa from Indian Institute of Technology Kharagpur; and the work unfolded entirely during the Covid-19 pandemic. We look forward to comments, questions, and feedback on the work from the broader scientific community.
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New pilot grant for hemodynamics using rotational angiography!

3/14/2022

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FLOWLab is honored to have been selected as one of the recipients of the Translational Methods Pilot Grant (TM-PILOT) award mechanism for a collaborative research effort on developing in silico patient specific models for congenital heart disease patients using standard-of-care 3D rotational angiography imaging. This is in collaboration with wonderful colleagues led by Dr. Jenny Zablah at the Children's Hospital of Colorado and the University of Colorado Anschutz Medical Campus. Here is the University of Colorado Boulder Paul M Rady Mechanical Engineering Department feature on our new project: https://www.colorado.edu/bme/2022/03/09/computer-simulated-heart-flow-model-could-help-treat-pediatric-heart-disease-patients. We thank the Colorado Clinical and Translational Sciences Institute (CCTSI) for this generous funding support! 
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Joseph wilson receives graduate teaching award!

3/14/2022

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FLOWLab member Joseph Wilson is one of the recipients of the David T. Spalding Graduate Teaching Fund Fellowship at the University of Colorado Boulder. Joseph's award comes in recognition of his contributions to teaching computational fluid dynamics, and going above and beyond a standard TA role to tackle challenges and complexities of teaching during the worldwide Covid-19 pandemic. Congratulations Joseph!
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Akshita sahni successfully defends her MS thesis!

11/16/2021

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FLOWLab MS Student Akshita Sahni her MS Thesis titled "Image-based In Silico Investigations for Hemodynamic Assessment in Patients with Left Ventricle Assist Devices". This interdisciplinary work was supported by a strong collaboration with Dr. Jay Pal from University of Colorado Anschutz Medical Campus, and funded by the Anschutz-Boulder Nexus (AB Nexus) Research Grant program. During her time Akshita has won an MS paper award at the Summer Biomechanics, Bioengineering and Biotransport (SB3C) conference 2021. Her stellar contributions are now being translated into multiple research manuscripts. Akshita will be temporarily continuing her stay with FLOWLab as she transitions into her next job. Congratulations Akshita! This is a proud moment for FLOWLab! 
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NEW MANUScript on flow-mediated infection transmission now out!

11/1/2021

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We are excited to announce the publication of our latest article on using computational fluid dynamics to develop a quantitative flow-mediated infection transmission metric that can be useful for deciding on infection control policies for occupied indoor spaces. The article titled "A Lagrangian Approach Towards Quantitative Analysis Of Flow-mediated Infection Transmission In Indoor Spaces With Application To SARS-COV-2" is now published in an invited special collection at the International Journal of Computational Fluid Dynamics. You can find the article on the journal webpage at this link, or on medRxiv at this link, or from our website Publications page. We thank our collaborator Prof. Shelly Miller at CU Boulder, and the lead graduate student Joseph Wilson for their work on this study. Please reach out to us with any feedback, discussions, comments - we are always on the lookout to engage with the scientific community.
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Congratulations Chayut for passing research prelims!

10/11/2021

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Join us in congratulating FLOWLab's first doctoral student Chayut Teeraratkul on passing his research preliminary examination with flying colors. We did not get to take a celebratory pic - but celebrations await as Chayut continues his successful journey through the doctoral program! 
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