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Here's what we have been up to!

Nick Rovito wins an Nsf GRFP award!

4/21/2025

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We are delighted to announce that FLOWLab doctoral trainee Nick Rovito is a recipient of the 2025 National Science Foundation Graduate Research Fellowship (GRFP) award! This award will support Nick's PhD research on advancing in silico modeling and quantitative analysis of vascular drug delivery techniques with a focus on thrombolytic therapy for acute ischemic stroke. This will also enable Nick to explore some of his interests in engineering education and pedagogy, enabling broader impacts of his work and building on some of FLOWLab's ongoing education and pedagogy work as well. Congratulations Nick on this well-deserved honor!
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flowlab undergraduate researcher presents at NCUR!

4/9/2025

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FLOWLab's undergraduate researcher Alena Tucker was selected to present her research at the recently held National Conference on Undergraduate Research (NCUR) at Pittsburgh. Organized by the Council on Undergraduate Research, this is a premiere scientific congregation focused on undergraduate research activities across the country. Alena presented her work on benchtop modeling of flow-mediated transport in cerebrovascular networks. This work was supported by the Discovery Learn Apprenticeship (DLA) program at the University of Colorado Boulder. The overall project also involved guidance and support from FLOWLab doctoral student Adiba Ashrafee. Alena's success is a testament to her hard work and dedication, and helps continue FLOWLab's strong record in undergraduate research training. Congratulations Alena! 
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New article on hemodynamics and stroke in patients on LVAD!

3/2/2025

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We at FLOWLab at University of Colorado Boulder College of Engineering & Applied Science are excited to share that our latest article "Hemodynamics indicates differences between patients with and without a stroke outcome after left ventricular assist device implantation." is now available online at Computers in Biology and Medicine!

Article Link: Click Here
FigShare (data+videos): Click Here
  1. We leveraged the idea of a "Digital Twin Cohort" of heart failure patients on Left Ventricular Assist Device (LVAD) support.
  2. We conducted a detailed hemodynamic assessment, comparing key flow descriptors against stroke vs no-stroke outcomes on LVAD support.
  3. Our findings indicate that post-implant hemodynamics - and - their alterations from pre-implant scenarios; can potentially reveal hidden information linked to stroke outcomes on LVAD support.
This work was made possible through funding by The National Institutes of Health (NIH) and the University of Colorado Anschutz Boulder Nexus Program. This is part of an ongoing long-term collaboration effort with Jay Pal and team at the University of Washington School of Medicine - Heart Institute; and reflects work done by several FLOWLab trainees: Akshita Sahni; Dr. Sreeparna Majee; and Kelly Cao.

There is more LVAD and mechanical circulatory support research underway at FLOWLab. Interested to learn more, collaborate, or discuss this article (or other works from our team)? Please send us an email; or reach out to our lab through our contacts page.
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NICK RoVito wins asme imece young engineer paper competition!

12/13/2024

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FLOWLab at the University of Colorado Boulder College of Engineering & Applied Science is delighted to share that our PhD trainee Nick Rovito was declared the winner (first-place) at the Young Engineer Paper (YEP) contest organized by the ASME Fluids Engineering Division (FED) at the recently concluded ASME IMECE 2024 in Portland, OR. Nick's award is in recognition of his research on in silico modeling of thrombolytic therapy for stroke; continuing on our research group's thematic emphasis on bringing advanced computational tools and models to understand physiological and pathological processes underlying diseases like stroke. This is a major recognition for student research, and we wholeheartedly congratulate Nick on his tremendous accomplishment!
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FLOwlab welcomes new members

10/16/2024

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It is a bit late into the academic year, but nevertheless it is a delight to share that FLOWLab celebrated the successful exits, and new transitions, for several members in our team. Post-doctoral scholar Sreeparna Majee, and undergraduate researchers Kelly Cao and Argudit Chauhan exited the group over the summer; while Chayut Teeraratkul completed his PhD, and transitioned over as a post-doctoral scholar. Undergraduate researcher Joshua Gregory continued to pursue an MS Thesis, joined newly by Manaswi Pulijala. Additionally, doctoral students Scott Malloy, Jessica Holmes, and Adiba Ashrafee joined the team. We are excited to continue on our research and education journey, with many new developments coming through!
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FLOWLab wins big at SB3C 2024!

6/17/2024

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FLOWLab members had a fantastic outing at the recently concluded SB3C 2024 meeting representing University of Colorado Boulder College of Engineering & Applied Science. FLOWLab doctoral trainee Chayut Teeraratkul secured First place in the PhD student paper competition for his research contribution on clot contraction mechanics. FLOWLab undergraduate trainee Argudit C. presented his research on cerebral collateral circulation as a finalist in the undergraduate paper competition. The SB3C Student Paper Competition is a hallmark of this trainee and early career friendly meeting, and winners are chosen after two rounds of rigorous scoring and reviewing. This goes to show the quality of effort that these two trainees have put in. Many congratulations to Chayut Teeraratkul for this fantastic achievement! 
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FLOWLab Celebrates Graduation and Awards!

6/11/2024

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FLOWLab was excited to celebrate a big graduation milestone this May 2024. FLOWLab had a fantastic graduation closeout with multiple happy updates reflecting the hard work of all trainees. Pictured here is FLOWLab's graduating cohort: Chayut Teeraratkul (PhD), Josh Gregory (BS-MS), Kelly Cao (BS), Argudit C. (BS), and Sarthak Samal (BS). Josh Gregory and Kelly Cao were awarded College Undergraduate Research Award, and Argudit C. was awarded a College Academic Engagement Award by the University of Colorado Boulder College of Engineering & Applied Science. In addition: Argudit C. also is a finalist at the upcoming SB3C org Undergraduate Student Paper Competition; and thereafter will be joining University of Colorado Anschutz Medical Campus for an MD. Chayut Teeraratkul got hooded as the first PhD student from FLOWLab; and is also a finalist at the upcoming SB3C org PhD Student Paper Competition. Last but not the least: FLOWLab's latest doctoral trainee Nick Rovito topped the end of semester off with an Outstanding Teaching Assistant Award in the Paul M Rady Department of Mechanical Engineering.

These successes are reflective of the efforts each of these trainees have put in; and present a snapshot of the talent and potential they will bring in to their professional domain as they continue to grow in their career. I also want to note that, in academia, successes are beautiful but infrequent at times. As we celebrate these moments, as mentors and peers, we need to also recognize the critical role of dedicated support and guidance through the difficult phases of research/training.

FLOWLab marches onwards! Congratulations to the team, graduating trainees, and their family and friends!
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latest article on cfd modeling using 3dra imaging now published!

3/18/2024

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FLOWLab is proud to announce the publication or our latest article titled "Computational Fluid Dynamic Assessment of Patients with Congenital Heart Disease from 3D Rotational Angiography" along with collaborators Jenny Zablah and Michael Shorofsky from Children's Colorado. The research presented in this article was spearheaded by talented FLOWLab undergraduate researcher Kelly Cao. We demonstrate the feasibility of utilizing a protocol that combines multi-planar reconstructed 3D rotational angiography imaging with cardiac catheterization lab hemodynamic data; to fully characterize the flow patterns in a reconstructive surgical anastomosis via CFD. You can find the article linked HERE. 
Please feel free to review our article, and reach out to us with any questions or comments! And congratulations to Kelly and our collaborators! 
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FLOWLab Had a successful Outing at APS-DFD 2023 Meeting!

11/24/2023

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FLOWLab team had an active and successful presence at the recently concluded 76th Annual Meeting of the American Physical Society Division of Fluid Dynamics meeting held at Washington DC. Our team presented a series of 5 technical talks, spanning various projects across the research program within the lab. The talks also featured our complete spectrum of trainees: undergraduate, MS, PhD, and post-doctoral. Congratulations to team FLOWLab on yet another successful APS DFD meeting!
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New Paper on energy dissipation in LVAD flows is now out!

6/22/2023

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We at FLOWLab are super excited to share the publication of our latest manuscript titled "The relation between viscous energy dissipation and pulsation for aortic hemodynamics driven by a left ventricular assist device" is now published and available at the BMES journal Cardiovascular Engineering and Technology at the following link: ​https://link.springer.com/article/10.1007/s13239-023-00670-6. 

This work involved contribution from FLOWLab members Akshita Sahni and Kelly Cao and collaborator Jay D. Pal from University of Washington, Seattle. We discuss the specific aspects of viscous energy transport and dissipation due to the altered state of hemodynamics driven by LVAD outflow jet impingement on the aorta wall. This work was funded by the University of Colorado Anschutz Boulder (AB) Nexus research collaboration grant. Check out our paper (you can download an accessible author pre-print from our Publications page). Congratulations Team!
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New Pre-print on biorxiv!

6/12/2023

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We are excited to announce FLOWLab's latest preprint available on bioRxiv (link here) on studying clot flow interactions in vivo by integrating intravital imaging with in silico modeling. This work is led by FLOWLab PhD student Chayu Teeraratkul in collaboration with Maurizio Tomaiuolo and Timothy Stalker.

Intravital imaging of mouse laser injury model can provide high resolution information on hemostatic processes in vivo. However, quantifying the local flow environment and flow-clot interactions require additional work. Here, we use custom numerical methods to fill in hemodynamic and clot-flow interaction information based on experimental data from mouse laser injury models. We can obtain not only the flow patterns, but also flow-induced loading on the clot, and flow-mediated chemical transport in the clot environment, all while accounting for dynamic deformation behavior of the clot itself. The methodology and model predictions are validated against direct experimental observations on caged fluorescent albumin transport dynamics in the mouse injury model. Feel free to check out the preprint, and reach out to us with any questions/comments.
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FLOWLab Presentations at the sb3c 2023 meeting

6/3/2023

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FLOWLab members are presenting 3 podium talks at the 2023 Summer Biomechanics, Bioengineering, and Biotransport Conference hosted at Vail, Colorado. Doctoral students Chayut Teeraratkul and Ricardo Roopnarinesingh, and post-doctoral scholar Sreeparna Majee, are presenting their research - showcasing the spectrum of stroke and thrombosis research in our group. Details attached in the image alongside. Congratulations Chayut, Ricardo, and Sreeparna!
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Advertising our new pre-print on embolic stroke

6/1/2023

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We at FLOWLab are happy to share the latest preprint from our group on MedRxiv on evidence and mechanisms for embolic stroke in contralateral hemispheres from carotid artery disease, available at:
https://www.medrxiv.org/content/10.1101/2023.04.20.23288892v1
This work is authored by FLOWLab member Ricardo Roopnarinesingh and collaborator Michelle Leppert, and is part of our NIH funded study on embolic stroke mechanics. We thank NIH for the funding support, and Dr. Leppert for the wonderful collaboration. Please check out the pre-print, and reach out to us if you have any questions!
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FLOWLAB Undergraduate Exchange student experience

6/1/2023

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Over Fall 2022 and Spring 2023, FLOWLab hosted Guillermo Munoz Ovejero and Alvaro Carpio Chicote as international undergraduate research exchange students. This summer, Guillermo and Alvaro completed their stint with FLOWLab. During this time, they worked on a tilt control mechanism for studying vascular flows. Pictured here is their exit presentation with the entire FLOWLab team. We congratulate Guillermo and Alvaro on their wonderful work, and thank them for spending research time with us. A special word of thanks to FLOWLab members Thomas Puhr and Tandralee Chetia, who served as mentors for Guillermo and Alvaro throughout their program. 
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FLOWLAb Research presented at AHA stroke conference!

2/9/2023

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FLOWLab was excited to share some of the ongoing research on stroke, thrombosis, and hemostasis in the lab with investigators and industry partners at the American Heart Association International Stroke Conference on February 8-10 at Dallas, TX. We shared some of our preliminary results on quantification of stroke risks in heart failure patients on Left Ventricular Assist Devices support, which was conducted by FLOWLab alumnus Akshita Sahni, and in collaboration with Dr. Jay D. Pal from University of Washington Seattle. We thank the National Institutes of Health and the University of Colorado Anschutz Boulder (AB) Nexus research collaboration program for funding our efforts in these directions. Please check out the abstract indexed in Stroke journal at the following link: Abstract Here. Thank you American Heart Association for such a wonderful platform for us to share our work!
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Congrats to two Freshly Minted FLOWLab Graduates!

12/15/2022

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Huge congratulations to Tom Puhr and Summer Andrews - FLOWLab's latest MS Thesis graduates!! This winter they got the chance to walk in their regalia in celebration of completing their MS degree. Both Tom and Summer completed amazing thesis research, paving the way for new research directions in the group! FLOWLab is ever so fortunate to have worked with you, will always be proud as well as supportive of all your future accomplishments, and wishes you all the very best of successes and prosperity ahead! Congratulations Tom and Summer!
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FLowlab's first undergraduate exchange students

12/15/2022

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This year FLOWLab hosted its very first set of undergraduate exchange students - Guillermo Munoz Ovejero and Alvaro Carpio Chicote - who visited us from Madrid, Spain. They are working as undergraduate researchers on a design project to create a tilt control system to study the impact of gravity on blood flow and embolisms. This work was supervised by FLOWLab MS Thesis student Tom Puhr, will continue under the supervision of MS Thesis student Tandralee Chetia. As the Fall semester ended, Guillermo and Alvaro presented status update on their research project. And boy are we excited to see what they continue to do as they rejoin us in the Spring to complete their exchange program! 
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FLOWLab presentations at APS-DFD 2022 in Indianapolis!

11/18/2022

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 FLOWLab members will be presenting a cross-section of some of our ongoing research efforts at the 75th Annual Technical Meeting of the American Physical Society Division of Fluid Dynamics. The complete list of presentations are provided in the photograph alongside. If you are attending APS-DFD as well, and/or are interested in any of these areas - please connect with us, and we would be happy to chat!

Looking forward to engaging with fellow fluid mechanicians at the APS DFD meeting. 

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Summer andrews successfully defends her ms thesis!

11/17/2022

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FLOWLab member and MS Thesis student Summer Andrews successfully defended her MS Thesis based on some awesome in silico modeling research on Trans-arterial Radioembolization in Hepato-cellular Carcinoma (liver cancers). Summer's research was born out of an inter-disciplinary collaboration with Dr. Premal Trivedi at the University of Colorado Anschutz Medical Campus. In addition to her research, Summer also served as a mentor for FLOWLab's virtual summer research internship program, and contributed to spearheading several FLOWLab socials. Congratulations Summer!
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Thomas Puhr Successfully Defends his MS Thesis!

11/15/2022

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FLOWLab member and MS Thesis student Thomas Puhr successfully defended his MS Thesis based on his amazing research on design and testing of an n vitro benchtop flow loop for investigation of embolic particle transport and distribution. This work was supported in its very early stages by the Oak Ridge Associated Universities (ORAU) through a Ralph Powe Junior Faculty Enhancement Award (awarded to FLOWLab PI Prof. Mukherjee). In addition to his research, Tom also served as mentor for the CU Science Discovery Program mentoring high school students, and served actively to advance FLOWLab's DEI initiatives. Congratulations Tom!
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