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Huge congratulations to Tom Puhr and Summer Andrews - FLOWLab's latest MS Thesis graduates!! This winter they got the chance to walk in their regalia in celebration of completing their MS degree. Both Tom and Summer completed amazing thesis research, paving the way for new research directions in the group! FLOWLab is ever so fortunate to have worked with you, will always be proud as well as supportive of all your future accomplishments, and wishes you all the very best of successes and prosperity ahead! Congratulations Tom and Summer!
FLOWLab is pleased to announce the release of a new preprint titled "The Relation Between Viscous Energy Dissipation And Pulsation For Aortic Hemodynamics Driven By A Left Ventricular Assist Device". This is the second manuscript in a series of manuscripts originating from a study on stroke risk assessment in heart failure patients on an LVAD support in collaboration with Dr. Jay Pal from University of Washington Seattle. The research was led by FLOWLab MS student Akshita Sahni, and ably supported by talented undergraduate student Kelly Cao. We are grateful for generous funding from the University of Colorado Anschutz-Boulder Nexus Research Collaboration Grant. The preprint can be accessed on medRxiv at this link. We look forward to comments, questions, and feedback from the broader scientific community.
FLOWLab is excited to announce that we have released a new preprint reporting a quantitative hemodynamic analysis for flow in the aorta of heart failure patients on mechanical circulatory support. This preprint is titled "Quantitative Assessment of Aortic Hemodynamics for Varying Left Ventricular Assist Device Outflow Graft Angles and Flow Pulsation" and is available on medRxiv at the following link: https://doi.org/10.1101/2022.06.17.22276555. This is the first in a series of forthcoming studies we have recently completed on hemodynamics in patients on LVAD support, and their interrelationship with stroke and cerebrovascular accident risks. The series of studies was led by Akshita Sahni, in collaboration with Dr. Jay D. Pal and Dr. Erin E. McIntyre. The study was supported by a University of Colorado Anschutz-Boulder Nexus Research Collaboration Grant. We look forward to comments, questions, and feedback from the broader scientific community.
We are excited to announce that we have a.new preprint on flow-mediated infection transmission for airborne infections, which combines social interaction dynamics models with fluid mechanics. Titled "A Mesoscale Agent Based Modeling Framework For Flow-mediated Infection Transmission In Indoor Occupied Spaces", this preprint can be accessed on medRxiv at this link. This is particularly exciting for us as this work was driven by our first remote visiting intern Gauri Wadhwa from Indian Institute of Technology Kharagpur; and the work unfolded entirely during the Covid-19 pandemic. We look forward to comments, questions, and feedback on the work from the broader scientific community.
FLOWLab is honored to have been selected as one of the recipients of the Translational Methods Pilot Grant (TM-PILOT) award mechanism for a collaborative research effort on developing in silico patient specific models for congenital heart disease patients using standard-of-care 3D rotational angiography imaging. This is in collaboration with wonderful colleagues led by Dr. Jenny Zablah at the Children's Hospital of Colorado and the University of Colorado Anschutz Medical Campus. Here is the University of Colorado Boulder Paul M Rady Mechanical Engineering Department feature on our new project: https://www.colorado.edu/bme/2022/03/09/computer-simulated-heart-flow-model-could-help-treat-pediatric-heart-disease-patients. We thank the Colorado Clinical and Translational Sciences Institute (CCTSI) for this generous funding support!
FLOWLab member Joseph Wilson is one of the recipients of the David T. Spalding Graduate Teaching Fund Fellowship at the University of Colorado Boulder. Joseph's award comes in recognition of his contributions to teaching computational fluid dynamics, and going above and beyond a standard TA role to tackle challenges and complexities of teaching during the worldwide Covid-19 pandemic. Congratulations Joseph!
FLOWLab MS Student Akshita Sahni her MS Thesis titled "Image-based In Silico Investigations for Hemodynamic Assessment in Patients with Left Ventricle Assist Devices". This interdisciplinary work was supported by a strong collaboration with Dr. Jay Pal from University of Colorado Anschutz Medical Campus, and funded by the Anschutz-Boulder Nexus (AB Nexus) Research Grant program. During her time Akshita has won an MS paper award at the Summer Biomechanics, Bioengineering and Biotransport (SB3C) conference 2021. Her stellar contributions are now being translated into multiple research manuscripts. Akshita will be temporarily continuing her stay with FLOWLab as she transitions into her next job. Congratulations Akshita! This is a proud moment for FLOWLab!  We are excited to announce the publication of our latest article on using computational fluid dynamics to develop a quantitative flow-mediated infection transmission metric that can be useful for deciding on infection control policies for occupied indoor spaces. The article titled "A Lagrangian Approach Towards Quantitative Analysis Of Flow-mediated Infection Transmission In Indoor Spaces With Application To SARS-COV-2" is now published in an invited special collection at the International Journal of Computational Fluid Dynamics. You can find the article on the journal webpage at this link, or on medRxiv at this link, or from our website Publications page. We thank our collaborator Prof. Shelly Miller at CU Boulder, and the lead graduate student Joseph Wilson for their work on this study. Please reach out to us with any feedback, discussions, comments - we are always on the lookout to engage with the scientific community.
Join us in congratulating FLOWLab's first doctoral student Chayut Teeraratkul on passing his research preliminary examination with flying colors. We did not get to take a celebratory pic - but celebrations await as Chayut continues his successful journey through the doctoral program!
FLOWLab is excited to announce an open position for a post-doctoral research associate who would be joining our diverse, interdisciplinary team to work on a research project on stroke biomechanics. This is a 2 year position, with an expected start date no earlier than January 2022. Please find the job advertisement and application details at the following link: https://jobs.colorado.edu/jobs/JobDetail/?jobId=33978 . Interested candidates are strongly encouraged to reach out to us for any inquiries. As an interdisciplinary research group set within an outstanding institution, we remain fiercely committed towards promoting a diverse, equitable, and inclusive environment. We encourage applicants from all backgrounds, especially those which are traditionally under-represented. Do not hesitate to contact us through the 'Contact' page on our website, or directly emailing debanjan@Colorado.Edu for any questions or clarifications.
FLOWLab is super excited to announce the publication of our latest article titled "Microstructure Aware Modeling Of Biochemical Transport In Arterial Blood Clots" in the Journal of Biomechanics. This article illustrates our ongoing work on microstructure aware modeling of thrombotic phenomena in arterial hemodynamics. We extend our custom fictitious domain approach for mesoscale modeling of heterogeneous blood clots. Specifically, here we outline the presence and formation of space-time varying coherent structures around an arterial clot that regulates advective transport. Furthermore, the heterogeneous microstructure representation enables us to model diffusive intra-thrombus transport. Using some cycle-averaged long time simulations we identify trends in intra-thrombus transport, based on an extension of the fictitious domain approach to advection-diffusion equations. Please find the journal version of the article at: https://www.sciencedirect.com/science/article/pii/S0021929021004607. You can also download an author's preprint version from bioRxiv at the following link: https://www.biorxiv.org/content/10.1101/2021.01.25.428179v2. We welcome comments and discussions from the community! Thank you also to all the reviewers and editors who helped with this publication during these challenging times.
FLOWLab MS student Joseph Wilson successfully defended his MS Thesis titled "Computational Modeling Of Viral Infection Transmission And Control In Indoor Spaces". Joseph's excellent work on this topic led to two journal publications (one published, and one under review), and four conference presentations. Joseph will continue his work with FLOWLab as a PhD student starting Fall 2021. Congratulations Joseph! This is a proud moment for FLOWLab!  FLOWLab researchers won key distinctions at the recently concluded Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C 2021). Akshita Sahni won the first prize at the MS Student Paper Competition for her work on characterizing aortic hemodynamics in patients with left ventricle assist device. Autumn Zemlicka won the runner-up prize at the BS Student Paper Competition for her work on flow mediated drug delivery in the hepatic circulation. Both projects were supported by collaborations with clinical investigators at CU Anschutz Medical Campus. Akshita's work was supported by the Anschutz Boulder Nexu (AB-Nexus) award mechanism. Congratulations Akshita and Autumn!!
We also thank ASME BED and SB3C for recognizing the hard work put in by these amazing students. Looking forward to more FLOWLab successes. FLOWLab is super excited to announce the publication of our latest article titled "Computational investigation of blood flow and flow mediated transport in arterial thrombus neighborhood" in the journal Biomechanics and Modeling in Mechanobiology. The article illustrates our continued work in the area of thrombosis and thrombus biomechanics. Using a custom computational method, and parametric numerical investigations, we show how advection, diffusion, and permeation processes are regulated by the flow around the clot, clot microstructure, and status of artery wall leakage at the location of the clot. Please find the journal version of the article at: https://link.springer.com/article/10.1007/s10237-020-01411-7 and if interested, you can also download a pre-publication version from BioRxiv at the following link: https://www.biorxiv.org/content/10.1101/2020.06.11.147488v2. We welcome comments and discussions from the community! Thank you also to all reviewers and editors who helped with the publication amidst these challenging times.
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