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FLOWLab wrapped up a successful edition of the ASME SB3C Summer Bioengineering Conference this past week. Team PI Debanjan Mukherjee was a part of the main conference organizing committee, in the capacity of information chair. FLOWLab doctoral trainee Ricardo Roopnarinesingh presented a poster on his work on computational pipeline to integrate medical images and clinical information into in silico models. FLOWLab undergraduate trainee Alena Tucker was one of the finalists of the SBC 2025 BS Student Paper Competition, where she presented our work on in vitro modeling of drug delivery in the brain. The team also took the time to grab a quick photograph with the beautiful views that the venue Santa Ana Pueblo, New Mexico offered.
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We are delighted to announce that FLOWLab doctoral trainee Nick Rovito is a recipient of the 2025 National Science Foundation Graduate Research Fellowship (GRFP) award! This award will support Nick's PhD research on advancing in silico modeling and quantitative analysis of vascular drug delivery techniques with a focus on thrombolytic therapy for acute ischemic stroke. This will also enable Nick to explore some of his interests in engineering education and pedagogy, enabling broader impacts of his work and building on some of FLOWLab's ongoing education and pedagogy work as well. Congratulations Nick on this well-deserved honor!
We at FLOWLab at University of Colorado Boulder College of Engineering & Applied Science are excited to share that our latest article "Hemodynamics indicates differences between patients with and without a stroke outcome after left ventricular assist device implantation." is now available online at Computers in Biology and Medicine!
Article Link: Click Here FigShare (data+videos): Click Here
There is more LVAD and mechanical circulatory support research underway at FLOWLab. Interested to learn more, collaborate, or discuss this article (or other works from our team)? Please send us an email; or reach out to our lab through our contacts page. FLOWLab at the University of Colorado Boulder College of Engineering & Applied Science is delighted to share that our PhD trainee Nick Rovito was declared the winner (first-place) at the Young Engineer Paper (YEP) contest organized by the ASME Fluids Engineering Division (FED) at the recently concluded ASME IMECE 2024 in Portland, OR. Nick's award is in recognition of his research on in silico modeling of thrombolytic therapy for stroke; continuing on our research group's thematic emphasis on bringing advanced computational tools and models to understand physiological and pathological processes underlying diseases like stroke. This is a major recognition for student research, and we wholeheartedly congratulate Nick on his tremendous accomplishment!
FLOWLab is proud to announce the publication or our latest article titled "Computational Fluid Dynamic Assessment of Patients with Congenital Heart Disease from 3D Rotational Angiography" along with collaborators Jenny Zablah and Michael Shorofsky from Children's Colorado. The research presented in this article was spearheaded by talented FLOWLab undergraduate researcher Kelly Cao. We demonstrate the feasibility of utilizing a protocol that combines multi-planar reconstructed 3D rotational angiography imaging with cardiac catheterization lab hemodynamic data; to fully characterize the flow patterns in a reconstructive surgical anastomosis via CFD. You can find the article linked HERE.
Please feel free to review our article, and reach out to us with any questions or comments! And congratulations to Kelly and our collaborators!
FLOWLab team had an active and successful presence at the recently concluded 76th Annual Meeting of the American Physical Society Division of Fluid Dynamics meeting held at Washington DC. Our team presented a series of 5 technical talks, spanning various projects across the research program within the lab. The talks also featured our complete spectrum of trainees: undergraduate, MS, PhD, and post-doctoral. Congratulations to team FLOWLab on yet another successful APS DFD meeting!
We at FLOWLab are super excited to share the publication of our latest manuscript titled "The relation between viscous energy dissipation and pulsation for aortic hemodynamics driven by a left ventricular assist device" is now published and available at the BMES journal Cardiovascular Engineering and Technology at the following link: https://link.springer.com/article/10.1007/s13239-023-00670-6.
This work involved contribution from FLOWLab members Akshita Sahni and Kelly Cao and collaborator Jay D. Pal from University of Washington, Seattle. We discuss the specific aspects of viscous energy transport and dissipation due to the altered state of hemodynamics driven by LVAD outflow jet impingement on the aorta wall. This work was funded by the University of Colorado Anschutz Boulder (AB) Nexus research collaboration grant. Check out our paper (you can download an accessible author pre-print from our Publications page). Congratulations Team! We are excited to announce FLOWLab's latest preprint available on bioRxiv (link here) on studying clot flow interactions in vivo by integrating intravital imaging with in silico modeling. This work is led by FLOWLab PhD student Chayu Teeraratkul in collaboration with Maurizio Tomaiuolo and Timothy Stalker.
Intravital imaging of mouse laser injury model can provide high resolution information on hemostatic processes in vivo. However, quantifying the local flow environment and flow-clot interactions require additional work. Here, we use custom numerical methods to fill in hemodynamic and clot-flow interaction information based on experimental data from mouse laser injury models. We can obtain not only the flow patterns, but also flow-induced loading on the clot, and flow-mediated chemical transport in the clot environment, all while accounting for dynamic deformation behavior of the clot itself. The methodology and model predictions are validated against direct experimental observations on caged fluorescent albumin transport dynamics in the mouse injury model. Feel free to check out the preprint, and reach out to us with any questions/comments.
We at FLOWLab are happy to share the latest preprint from our group on MedRxiv on evidence and mechanisms for embolic stroke in contralateral hemispheres from carotid artery disease, available at:
https://www.medrxiv.org/content/10.1101/2023.04.20.23288892v1 This work is authored by FLOWLab member Ricardo Roopnarinesingh and collaborator Michelle Leppert, and is part of our NIH funded study on embolic stroke mechanics. We thank NIH for the funding support, and Dr. Leppert for the wonderful collaboration. Please check out the pre-print, and reach out to us if you have any questions!
Huge congratulations to Tom Puhr and Summer Andrews - FLOWLab's latest MS Thesis graduates!! This winter they got the chance to walk in their regalia in celebration of completing their MS degree. Both Tom and Summer completed amazing thesis research, paving the way for new research directions in the group! FLOWLab is ever so fortunate to have worked with you, will always be proud as well as supportive of all your future accomplishments, and wishes you all the very best of successes and prosperity ahead! Congratulations Tom and Summer!
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