FLOWLab is super excited to announce the publication of our latest article titled "Microstructure Aware Modeling Of Biochemical Transport In Arterial Blood Clots" in the Journal of Biomechanics. This article illustrates our ongoing work on microstructure aware modeling of thrombotic phenomena in arterial hemodynamics. We extend our custom fictitious domain approach for mesoscale modeling of heterogeneous blood clots. Specifically, here we outline the presence and formation of space-time varying coherent structures around an arterial clot that regulates advective transport. Furthermore, the heterogeneous microstructure representation enables us to model diffusive intra-thrombus transport. Using some cycle-averaged long time simulations we identify trends in intra-thrombus transport, based on an extension of the fictitious domain approach to advection-diffusion equations. Please find the journal version of the article at: https://www.sciencedirect.com/science/article/pii/S0021929021004607. You can also download an author's preprint version from bioRxiv at the following link: https://www.biorxiv.org/content/10.1101/2021.01.25.428179v2. We welcome comments and discussions from the community! Thank you also to all the reviewers and editors who helped with this publication during these challenging times.
FLOWLab MS student Joseph Wilson successfully defended his MS Thesis titled "Computational Modeling Of Viral Infection Transmission And Control In Indoor Spaces". Joseph's excellent work on this topic led to two journal publications (one published, and one under review), and four conference presentations. Joseph will continue his work with FLOWLab as a PhD student starting Fall 2021. Congratulations Joseph! This is a proud moment for FLOWLab!
FLOWLab researchers won key distinctions at the recently concluded Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C 2021). Akshita Sahni won the first prize at the MS Student Paper Competition for her work on characterizing aortic hemodynamics in patients with left ventricle assist device. Autumn Zemlicka won the runner-up prize at the BS Student Paper Competition for her work on flow mediated drug delivery in the hepatic circulation. Both projects were supported by collaborations with clinical investigators at CU Anschutz Medical Campus. Akshita's work was supported by the Anschutz Boulder Nexu (AB-Nexus) award mechanism. Congratulations Akshita and Autumn!!
We also thank ASME BED and SB3C for recognizing the hard work put in by these amazing students. Looking forward to more FLOWLab successes.
FLOWLab is super excited to announce the publication of our latest article titled "Computational investigation of blood flow and flow mediated transport in arterial thrombus neighborhood" in the journal Biomechanics and Modeling in Mechanobiology. The article illustrates our continued work in the area of thrombosis and thrombus biomechanics. Using a custom computational method, and parametric numerical investigations, we show how advection, diffusion, and permeation processes are regulated by the flow around the clot, clot microstructure, and status of artery wall leakage at the location of the clot. Please find the journal version of the article at: https://link.springer.com/article/10.1007/s10237-020-01411-7 and if interested, you can also download a pre-publication version from BioRxiv at the following link: https://www.biorxiv.org/content/10.1101/2020.06.11.147488v2. We welcome comments and discussions from the community! Thank you also to all reviewers and editors who helped with the publication amidst these challenging times.
FLOWLab is super excited to have the work done by two of our amazing women engineers - Akshita Sahni and Autumn Zemlicka - be featured on the Pretty Brainy (https://prettybrainy.com/) blog. Pretty Brainy is an education non-profit organization with the goal of empowering girls develop their STEAM abilities and genius to positively impact their communities and world. You can find the article featuring our work at the following link: https://prettybrainy.com/computer-aided-design/
We here at FLOWLab are fortunate to be working with highly talented women engineers like Akshita and Autumn, and it is a matter of pride and joy for all of us here at FLOWLab to see their work and contributions getting wide recognition. Keep up the awesome stuff Akshita and Autumn! Finally, kudos also to Pretty Brainy for all the great work they are doing to empower young girls to become future STEAM leaders! Thank you Pretty Brainy!
We are excited to announce the publication of a new article by Prof. Mukherjee on engineering education, available on the inaugural issue of the journal of Biomedical Engineering Education by BMES. The article provides insights into remote teaching of computational flow physics concepts for engineering students in remote and online teaching modalities. FLOWLab is excited to have made this contribution on a topic that is extremely relevant in modern engineering education especially considering the unprecedented challenges thrown by the ongoing Covid-19 pandemic. The article can be accessed online at the following link: https://link.springer.com/article/10.1007/s43683-020-00044-7 - and interested viewers can also access an Author's copy from the Research Publications page on our website! We look forward to hearing from interested researchers and educators in the community!
The FLOWLab is super excited to share University of Colorado Boulder Paul M Rady Mechanical Engineering feature story on our stroke research which earned a Trailblazer research grant worth $584,000.00 from NIBIB-NIH! Please find the story feature in the following link: https://www.colorado.edu/mechanical/2020/12/19/researchers-develop-patient-specific-models-prevent-repeat-strokes
We wholeheartedly thank NIH for their generous support towards our research! Huge thanks to awesome collaborators: Jonathan Coutinho, Valeria Guglielmi from AMC Amsterdam; and Michelle Leppert from CU Anschutz Medical Campus!
FLOWLab receives one of the inaugural seed grants from the University of Colorado Anschutz Boulder Nexus program. This grant is recognizing our work on stroke in heart failure patients treated with Left Ventricle Assist Devices (LVADs) in collaboration with Dr. Jay Pal and his team at CU Anschutz Cardiothoracic Surgery. FLOWLab member Akshita Sahni has been a key player in this project. Read more about the grant recipients at this link and read CU Mechanical Engineering news feature on this grant at this link.
Thank you for your support AB Nexus!
FLOWLab researchers have a strong presence at the 73rd Annual Technical Meeting of the American Physical Society Division of Fluid Dynamics meeting - more popularly referred to in fluids community as APS-DFD. The meeting is held virtually this year. Fellow DFD participants, come check out our presentations at the sessions listed below!
It is official! Prof. Mukherjee is one of the recipients of the National Institutes of Health (NIH) Trailblazer Award for new and early career faculty. The award is administered through the NIH National Institute of Biomedical Imaging and Bioengineering. This award recognizes our proposed research efforts in developing in silico technologies for advancing diagnosis and treatment of embolic strokes. Stroke continues to be a major cause of death and disability worldwide. Latest statistics form the American Heart Association reveal that a stroke is reported in the United States approximately around every 40 seconds. FLOWLab will be working on this along with collaborators from AMC Amsterdam in the Netherlands, and University of Colorado Anschutz Medical Campus. We thank the National Institutes of Health for their generosity and support - especially at this early stage for Prof. Mukherjee. We are truly grateful to have been given this opportunity.
More on this award and research coming soon ...