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We are excited to announce that we have a.new preprint on flow-mediated infection transmission for airborne infections, which combines social interaction dynamics models with fluid mechanics. Titled "A Mesoscale Agent Based Modeling Framework For Flow-mediated Infection Transmission In Indoor Occupied Spaces", this preprint can be accessed on medRxiv at this link. This is particularly exciting for us as this work was driven by our first remote visiting intern Gauri Wadhwa from Indian Institute of Technology Kharagpur; and the work unfolded entirely during the Covid-19 pandemic. We look forward to comments, questions, and feedback on the work from the broader scientific community.
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FLOWLab is honored to have been selected as one of the recipients of the Translational Methods Pilot Grant (TM-PILOT) award mechanism for a collaborative research effort on developing in silico patient specific models for congenital heart disease patients using standard-of-care 3D rotational angiography imaging. This is in collaboration with wonderful colleagues led by Dr. Jenny Zablah at the Children's Hospital of Colorado and the University of Colorado Anschutz Medical Campus. Here is the University of Colorado Boulder Paul M Rady Mechanical Engineering Department feature on our new project: https://www.colorado.edu/bme/2022/03/09/computer-simulated-heart-flow-model-could-help-treat-pediatric-heart-disease-patients. We thank the Colorado Clinical and Translational Sciences Institute (CCTSI) for this generous funding support!
FLOWLab member Joseph Wilson is one of the recipients of the David T. Spalding Graduate Teaching Fund Fellowship at the University of Colorado Boulder. Joseph's award comes in recognition of his contributions to teaching computational fluid dynamics, and going above and beyond a standard TA role to tackle challenges and complexities of teaching during the worldwide Covid-19 pandemic. Congratulations Joseph!
FLOWLab MS Student Akshita Sahni her MS Thesis titled "Image-based In Silico Investigations for Hemodynamic Assessment in Patients with Left Ventricle Assist Devices". This interdisciplinary work was supported by a strong collaboration with Dr. Jay Pal from University of Colorado Anschutz Medical Campus, and funded by the Anschutz-Boulder Nexus (AB Nexus) Research Grant program. During her time Akshita has won an MS paper award at the Summer Biomechanics, Bioengineering and Biotransport (SB3C) conference 2021. Her stellar contributions are now being translated into multiple research manuscripts. Akshita will be temporarily continuing her stay with FLOWLab as she transitions into her next job. Congratulations Akshita! This is a proud moment for FLOWLab!  We are excited to announce the publication of our latest article on using computational fluid dynamics to develop a quantitative flow-mediated infection transmission metric that can be useful for deciding on infection control policies for occupied indoor spaces. The article titled "A Lagrangian Approach Towards Quantitative Analysis Of Flow-mediated Infection Transmission In Indoor Spaces With Application To SARS-COV-2" is now published in an invited special collection at the International Journal of Computational Fluid Dynamics. You can find the article on the journal webpage at this link, or on medRxiv at this link, or from our website Publications page. We thank our collaborator Prof. Shelly Miller at CU Boulder, and the lead graduate student Joseph Wilson for their work on this study. Please reach out to us with any feedback, discussions, comments - we are always on the lookout to engage with the scientific community.
Join us in congratulating FLOWLab's first doctoral student Chayut Teeraratkul on passing his research preliminary examination with flying colors. We did not get to take a celebratory pic - but celebrations await as Chayut continues his successful journey through the doctoral program!
FLOWLab is excited to announce an open position for a post-doctoral research associate who would be joining our diverse, interdisciplinary team to work on a research project on stroke biomechanics. This is a 2 year position, with an expected start date no earlier than January 2022. Please find the job advertisement and application details at the following link: https://jobs.colorado.edu/jobs/JobDetail/?jobId=33978 . Interested candidates are strongly encouraged to reach out to us for any inquiries. As an interdisciplinary research group set within an outstanding institution, we remain fiercely committed towards promoting a diverse, equitable, and inclusive environment. We encourage applicants from all backgrounds, especially those which are traditionally under-represented. Do not hesitate to contact us through the 'Contact' page on our website, or directly emailing [email protected] for any questions or clarifications.
FLOWLab is super excited to announce the publication of our latest article titled "Microstructure Aware Modeling Of Biochemical Transport In Arterial Blood Clots" in the Journal of Biomechanics. This article illustrates our ongoing work on microstructure aware modeling of thrombotic phenomena in arterial hemodynamics. We extend our custom fictitious domain approach for mesoscale modeling of heterogeneous blood clots. Specifically, here we outline the presence and formation of space-time varying coherent structures around an arterial clot that regulates advective transport. Furthermore, the heterogeneous microstructure representation enables us to model diffusive intra-thrombus transport. Using some cycle-averaged long time simulations we identify trends in intra-thrombus transport, based on an extension of the fictitious domain approach to advection-diffusion equations. Please find the journal version of the article at: https://www.sciencedirect.com/science/article/pii/S0021929021004607. You can also download an author's preprint version from bioRxiv at the following link: https://www.biorxiv.org/content/10.1101/2021.01.25.428179v2. We welcome comments and discussions from the community! Thank you also to all the reviewers and editors who helped with this publication during these challenging times.
FLOWLab MS student Joseph Wilson successfully defended his MS Thesis titled "Computational Modeling Of Viral Infection Transmission And Control In Indoor Spaces". Joseph's excellent work on this topic led to two journal publications (one published, and one under review), and four conference presentations. Joseph will continue his work with FLOWLab as a PhD student starting Fall 2021. Congratulations Joseph! This is a proud moment for FLOWLab!  FLOWLab researchers won key distinctions at the recently concluded Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C 2021). Akshita Sahni won the first prize at the MS Student Paper Competition for her work on characterizing aortic hemodynamics in patients with left ventricle assist device. Autumn Zemlicka won the runner-up prize at the BS Student Paper Competition for her work on flow mediated drug delivery in the hepatic circulation. Both projects were supported by collaborations with clinical investigators at CU Anschutz Medical Campus. Akshita's work was supported by the Anschutz Boulder Nexu (AB-Nexus) award mechanism. Congratulations Akshita and Autumn!!
We also thank ASME BED and SB3C for recognizing the hard work put in by these amazing students. Looking forward to more FLOWLab successes. FLOWLab is super excited to announce the publication of our latest article titled "Computational investigation of blood flow and flow mediated transport in arterial thrombus neighborhood" in the journal Biomechanics and Modeling in Mechanobiology. The article illustrates our continued work in the area of thrombosis and thrombus biomechanics. Using a custom computational method, and parametric numerical investigations, we show how advection, diffusion, and permeation processes are regulated by the flow around the clot, clot microstructure, and status of artery wall leakage at the location of the clot. Please find the journal version of the article at: https://link.springer.com/article/10.1007/s10237-020-01411-7 and if interested, you can also download a pre-publication version from BioRxiv at the following link: https://www.biorxiv.org/content/10.1101/2020.06.11.147488v2. We welcome comments and discussions from the community! Thank you also to all reviewers and editors who helped with the publication amidst these challenging times.
FLOWLab is super excited to have the work done by two of our amazing women engineers - Akshita Sahni and Autumn Zemlicka - be featured on the Pretty Brainy (https://prettybrainy.com/) blog. Pretty Brainy is an education non-profit organization with the goal of empowering girls develop their STEAM abilities and genius to positively impact their communities and world. You can find the article featuring our work at the following link: https://prettybrainy.com/computer-aided-design/
We here at FLOWLab are fortunate to be working with highly talented women engineers like Akshita and Autumn, and it is a matter of pride and joy for all of us here at FLOWLab to see their work and contributions getting wide recognition. Keep up the awesome stuff Akshita and Autumn! Finally, kudos also to Pretty Brainy for all the great work they are doing to empower young girls to become future STEAM leaders! Thank you Pretty Brainy! We are excited to announce the publication of a new article by Prof. Mukherjee on engineering education, available on the inaugural issue of the journal of Biomedical Engineering Education by BMES. The article provides insights into remote teaching of computational flow physics concepts for engineering students in remote and online teaching modalities. FLOWLab is excited to have made this contribution on a topic that is extremely relevant in modern engineering education especially considering the unprecedented challenges thrown by the ongoing Covid-19 pandemic. The article can be accessed online at the following link: https://link.springer.com/article/10.1007/s43683-020-00044-7 - and interested viewers can also access an Author's copy from the Research Publications page on our website! We look forward to hearing from interested researchers and educators in the community!
The FLOWLab is super excited to share University of Colorado Boulder Paul M Rady Mechanical Engineering feature story on our stroke research which earned a Trailblazer research grant worth $584,000.00 from NIBIB-NIH! Please find the story feature in the following link: https://www.colorado.edu/mechanical/2020/12/19/researchers-develop-patient-specific-models-prevent-repeat-strokes
We wholeheartedly thank NIH for their generous support towards our research! Huge thanks to awesome collaborators: Jonathan Coutinho, Valeria Guglielmi from AMC Amsterdam; and Michelle Leppert from CU Anschutz Medical Campus! FLOWLab receives one of the inaugural seed grants from the University of Colorado Anschutz Boulder Nexus program. This grant is recognizing our work on stroke in heart failure patients treated with Left Ventricle Assist Devices (LVADs) in collaboration with Dr. Jay Pal and his team at CU Anschutz Cardiothoracic Surgery. FLOWLab member Akshita Sahni has been a key player in this project. Read more about the grant recipients at this link and read CU Mechanical Engineering news feature on this grant at this link.
Thank you for your support AB Nexus! FLOWLab researchers have a strong presence at the 73rd Annual Technical Meeting of the American Physical Society Division of Fluid Dynamics meeting - more popularly referred to in fluids community as APS-DFD. The meeting is held virtually this year. Fellow DFD participants, come check out our presentations at the sessions listed below!
It is official! Prof. Mukherjee is one of the recipients of the National Institutes of Health (NIH) Trailblazer Award for new and early career faculty. The award is administered through the NIH National Institute of Biomedical Imaging and Bioengineering. This award recognizes our proposed research efforts in developing in silico technologies for advancing diagnosis and treatment of embolic strokes. Stroke continues to be a major cause of death and disability worldwide. Latest statistics form the American Heart Association reveal that a stroke is reported in the United States approximately around every 40 seconds. FLOWLab will be working on this along with collaborators from AMC Amsterdam in the Netherlands, and University of Colorado Anschutz Medical Campus. We thank the National Institutes of Health for their generosity and support - especially at this early stage for Prof. Mukherjee. We are truly grateful to have been given this opportunity.
More on this award and research coming soon ... Prof. Mukherjee is one of the recipients of the Oak Ridge Associated Universities (ORAU) Ralph E. Powe Junior Faculty Enhancement Awards! This award was given in recognition of Prof. Mukherjee's research expertise in cardiovascular sciences and his research proposal on developing a benchtop flow loop system for studying embolic stroke. This is one of FLOWLab's first research grants to enable developing a bench-top experimental set-up in our group. Read the Paul M Rady Department of Mechanical Engineering news post on Prof. Mukherjee's award here:
https://www.colorado.edu/mechanical/2020/09/28/mukherjee-receives-ralph-e-powe-junior-faculty-enhancement-award You can also check out the Ralph E. Powe Awards page here: https://www.orau.org/university-partnerships/member-grant-programs/powe/index.html Thank you so much for your support Oak Ridge Associated Universities and the Ralph E. Powe Award Committee! FLOWLab member Andrew Beiter was a participant in the SPUR (Summer Program for Undergraduate Research) in Paul M Rady Department of Mechanical Engineering at CU Boulder. His work focused on developing computational models and simulations for embolus transport for assessment of embolic stroke in heart failure patients treated with LVAD. His work is featured on the ME Department website:
https://www.colorado.edu/mechanical/2020/09/11/me-spur-experience-beiter-researches-image-based-modeling-cardiovascular-systems Congratulations Andrew! Our manuscript on SARS-CoV-2 infection control and management in skilled nursing facilities has recently been accepted in the American Journal of Infection Control. This work was in collaboration with Shelly Miller from CU Boulder, Nicholas Clements from Mayo Clinic, and Cedric Steiner from Eastern University, Pennsylvania. Titled: "Implementing a Negative Pressure Isolation Space within a Skilled Nursing Facility to Control SARS-CoV-2 Transmission", pre-print of the manuscript can be accessed from medRxiv (see Research Publications page). Nursing and long-term facilities have been most severely impacted by the Covid-19 pandemic. Isolation spaces can be an effective strategy to manage infection control and meet surge capacity during a pandemic. In this study we implemented a negative pressure isolation space at a nursing facility in Pennsylvania, guided by computational flow physics models and on-site pressure measurements. The study was highly successful resulting in smooth operation, zero transmission, and zero fatalities in the facility during the course of the study. FLOWLab PI Debanjan Mukherjee, and graduate student Joseph Wilson participated in this study and co-authored the manuscript. Our group continues to expand this investigation on respiratory infection control and management in indoor facilities. We will be happy to answer any questions you may have, or any interest in this topic in general. Meanwhile, check out our paper on medRxiv!
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