We are excited to announce FLOWLab's latest preprint available on bioRxiv (link here) on studying clot flow interactions in vivo by integrating intravital imaging with in silico modeling. This work is led by FLOWLab PhD student Chayu Teeraratkul in collaboration with Maurizio Tomaiuolo and Timothy Stalker.
Intravital imaging of mouse laser injury model can provide high resolution information on hemostatic processes in vivo. However, quantifying the local flow environment and flow-clot interactions require additional work. Here, we use custom numerical methods to fill in hemodynamic and clot-flow interaction information based on experimental data from mouse laser injury models. We can obtain not only the flow patterns, but also flow-induced loading on the clot, and flow-mediated chemical transport in the clot environment, all while accounting for dynamic deformation behavior of the clot itself. The methodology and model predictions are validated against direct experimental observations on caged fluorescent albumin transport dynamics in the mouse injury model. Feel free to check out the preprint, and reach out to us with any questions/comments.